Bone fracture and bone fracture repair

被引：127

作者：

Fazzalari, N. L. ^{[1
,2
]}

机构：

[1] SA Pathol & Hanson Inst, Bone & Joint Res Lab, Adelaide, SA 5000, Australia

[2] Univ Adelaide, Discipline Pathol, Adelaide, SA 5000, Australia

来源：

OSTEOPOROSIS INTERNATIONAL | 2011年 / 22卷 / 06期

关键词：

Fracture; Fracture repair; Microdamage; Stress fracture; MICRODAMAGE; EXPRESSION; FRAGILITY;

D O I：

10.1007/s00198-011-1611-4

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Fracture healing is a multistage repair process that involves complex, well-orchestrated steps initiated in response to tissue injury. The early upregulation of IL-6, osteoprotegerin (OPG), VEGF, and BMPs indicates a central role for these factors in the initiation of cartilage and periosteal woven bone formation. In both callus fracture repair and stress fracture repair, the RANKL/OPG ratio is initially reduced, but peaks earlier in stress fracture healing than callus fracture healing. Though the understanding of the biological processes and molecular signals that coordinate fracture repair has advanced, the cause of variability observed in fracture repair is poorly understood.

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收藏

页码：2003 / 2006

页数：4

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