Incorporation of a novel nucleobase allows stable oligonucleotide-directed triple helix formation at the target sequence containing a purine•pyrimidine interruption

被引：68

作者：

Guianvarc'h, D

Benhida, R

Fourrey, JL

Maurisse, R

Sun, JS

机构：

[1] Museum Natl Hist Nat, INSERM, U201, CNRS,UMR 8646,Lab Biophys, F-75231 Paris 05, France

[2] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 18期

关键词：

D O I：

10.1039/b103743a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thermal denaturation experiments have established that an oligonucleotide incorporating the artificial nucleobase S, does form a stable triplex with a double stranded DNA which exhibits a pyrimidine interruption within the oligopurine sequence.

引用

页码：1814 / 1815

页数：2

共 26 条

[1] ENERGETICS OF FORMATION OF 16 TRIPLE-HELICAL COMPLEXES WHICH VARY AT A SINGLE POSITION WITHIN A PYRIMIDINE MOTIF [J].

BEST, GC ;

DERVAN, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (04) :1187-1193

[2] Towards a general triple helix mediated DNA recognition scheme [J].

Doronina, SO ;

Behr, JP .

CHEMICAL SOCIETY REVIEWS, 1997, 26 (01) :63-71

[3] TRIPLEX DNA STRUCTURES [J].

FRANKKAMENETSKII, MD ;

MIRKIN, SM .

ANNUAL REVIEW OF BIOCHEMISTRY, 1995, 64 :65-95

[4] Selective recognition of a dC-dG base pair by oligonucleotide-directed triplex formation using a dC residue tethering an intercalator [J].

Gianolio, DA ;

McLaughlin, LW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (26) :6334-6335

[5] Progress in developments of triplex-based strategies [J].

Giovannangeli, C ;

Helene, C .

ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 1997, 7 (04) :413-421

[6] Towards mixed sequence recognition by triple helix formation [J].

Gowers, DM ;

Fox, KR .

NUCLEIC ACIDS RESEARCH, 1999, 27 (07) :1569-1577

[7] ENERGETICS OF FORMATION OF 16 TRIPLE-HELICAL COMPLEXES WHICH VARY AT A SINGLE POSITION WITHIN A PURINE MOTIF [J].

GREENBERG, WA ;

DERVAN, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (18) :5016-5022

[8] RECOGNITION OF ALL 4 BASE-PAIRS OF DOUBLE-HELICAL DNA BY TRIPLE-HELIX FORMATION - DESIGN OF NONNATURAL DEOXYRIBONUCLEOSIDES FOR PYRIMIDINE.PURINE BASE PAIR BINDING [J].

GRIFFIN, LC ;

KIESSLING, LL ;

BEAL, PA ;

GILLESPIE, P ;

DERVAN, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (21) :7976-7982

[9] C-glycoside phosphoramidite building block for versatile functionalization of oligodeoxyribonucleotides [J].

Hovinen, J ;

Salo, H .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1997, (20) :3017-3020

[10] TRIPLEX FORMATION BY AN OLIGONUCLEOTIDE CONTAINING N(4)-(3-ACETAMIDOPROPYL)CYTOSINE [J].

HUANG, CY ;

CUSHMAN, CD ;

MILLER, PS .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (19) :5048-5049

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