Probing disaccharide selectivity with modular fluorescent sensors

被引：33

作者：

Arimori, S ^{[1
]}

Phillips, MD ^{[1
]}

James, TD ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

disaccharide; recognition; fluorescence sensor; boronic acid;

D O I：

10.1016/j.tetlet.2003.12.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Six modular photoinduced electron transfer (PET) sensors bearing two phenylboronic acid receptors have been evaluated as fluorescent disaccharide sensors. The length of linker separating the two boronic acid moieties was varied and the sensors' interaction with disaccharides assessed via fluorescence spectroscopy. It was shown that saccharide selectivity was influenced by the choice of linker length. Diboronic acid sensors 3(n) also displayed significant specificity for the disaccharides linked to the carbon on the 3rd or 6th position (as numbered from the anomeric centre) over those linked at the 4th position. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1539 / 1542

页数：4

共 31 条

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