Asymmetric synthesis of 3,3-diarylpropanals with chiral diene-rhodium catalysts

被引：235

作者：

Paquin, JF ^{[1
]}

Defieber, C ^{[1
]}

Stephenson, CRJ ^{[1
]}

Carreira, EM ^{[1
]}

机构：

[1] ETH Honggerberg, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 31期

关键词：

D O I：

10.1021/ja053270w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general route to enantioenriched 3,3-diarylpropanals is presented. These useful building blocks are prepared via an asymmetric rhodium-catalyzed conjugate addition of arylboronic acids to cinnamaldehyde derivatives in the presence of chiral dienes. The addition of both electron-poor as well as electron-rich boronic acids proceeds smoothly with various enals in 63-90% yield with high enantioselectivities (89-93% ee). Copyright © 2005 American Chemical Society.

引用

页码：10850 / 10851

页数：2

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