Triggering antiviral response by RIG-I-related RNA helicases

被引：60

作者：

Fujita, Takashi ^{[1
]}

Onoguchi, Kazuhide ^{[1
]}

Onomoto, Koji ^{[1
]}

Hirai, Reiko ^{[1
]}

Yoneyama, Mitsutoshi ^{[1
]}

机构：

[1] Kyoto Univ, Inst Virus Res, Mol Genet Lab, Kyoto 6068507, Japan

来源：

BIOCHIMIE | 2007年 / 89卷 / 6-7期

关键词：

interferon; RNA helicase; innate immunity; TLR; double-stranded RNA;

D O I：

10.1016/j.biochi.2007.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses. (C) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：754 / 760

页数：7

共 63 条

[1] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].

Alexopoulou, L ;

Holt, AC ;

Medzhitov, R ;

Flavell, RA .

NATURE, 2001, 413 (6857) :732-738

[2] The pathogenic NY-1 hantavirus G1 cytoplasmic tail inhibits RIG-I- and TBK-1-directed interferon responses [J].

Alff, Peter J. ;

Gavrilovskaya, Irina N. ;

Gorbunova, Elena ;

Endriss, Karen ;

Chong, Yuson ;

Geimonen, Erika ;

Sen, Nandini ;

Reich, Nancy C. ;

Mackow, Erich R. .

JOURNAL OF VIROLOGY, 2006, 80 (19) :9676-9686

[3] The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-β promoter [J].

Andrejeva, J ;

Childs, KS ;

Young, DF ;

Carlos, TS ;

Stock, N ;

Goodbourn, S ;

Randall, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (49) :17264-17269

[4] TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling [J].

Bin, LH ;

Xu, LG ;

Shu, HB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (27) :24526-24532

[5] Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling [J].

Cardenas, Washington B. ;

Loo, Yueh-Ming ;

Gale, Michael, Jr. ;

Hartman, Amy L. ;

Kimberlin, Christopher R. ;

Martinez-Sobrido, Luis ;

Saphire, Erica Ollmann ;

Basler, Christopher F. .

JOURNAL OF VIROLOGY, 2006, 80 (11) :5168-5178

[6] Plasmacytoid dendritic cells in immunity [J].

Colonna, M ;

Trinchieri, G ;

Liu, YJ .

NATURE IMMUNOLOGY, 2004, 5 (12) :1219-1226

[7] Viral infection switches non-plasmacytoid dendritic cells into high interferon producers [J].

Diebold, SS ;

Montoya, M ;

Unger, H ;

Alexopoulou, L ;

Roy, P ;

Haswell, LE ;

Al-Shamkhani, A ;

Flavell, R ;

Borrow, P ;

Sousa, CRE .

NATURE, 2003, 424 (6946) :324-328

[8] AN ATF/CREB BINDING-SITE PROTEIN IS REQUIRED FOR VIRUS INDUCTION OF THE HUMAN INTERFERON BETA GENE [J].

DU, W ;

MANIATIS, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) :2150-2154

[9] IKKε and TBK1 are essential components of the IRF3 signaling pathway [J].

Fitzgerald, KA ;

McWhirter, SM ;

Faia, KL ;

Rowe, DC ;

Latz, E ;

Golenbock, DT ;

Coyle, AJ ;

Liao, SM ;

Maniatis, T .

NATURE IMMUNOLOGY, 2003, 4 (05) :491-496

[10] LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the toll adapters TRAM and TRIF [J].

Fitzgerald, KA ;

Rowe, DC ;

Barnes, BJ ;

Caffrey, DR ;

Visintin, A ;

Latz, E ;

Monks, B ;

Pitha, PM ;

Golenbock, DT .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (07) :1043-1055

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