Triggering antiviral response by RIG-I-related RNA helicases

被引：60

作者：

Fujita, Takashi ^{[1
]}

Onoguchi, Kazuhide ^{[1
]}

Onomoto, Koji ^{[1
]}

Hirai, Reiko ^{[1
]}

Yoneyama, Mitsutoshi ^{[1
]}

机构：

[1] Kyoto Univ, Inst Virus Res, Mol Genet Lab, Kyoto 6068507, Japan

来源：

BIOCHIMIE | 2007年 / 89卷 / 6-7期

关键词：

interferon; RNA helicase; innate immunity; TLR; double-stranded RNA;

D O I：

10.1016/j.biochi.2007.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses. (C) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：754 / 760

页数：7

共 63 条

[41] The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I [J].

Rothenfusser, S ;

Goutagny, N ;

DiPerna, G ;

Gong, M ;

Monks, BG ;

Schoenemeyer, A ;

Yamamoto, M ;

Akira, S ;

Fitzgerald, KA .

JOURNAL OF IMMUNOLOGY, 2005, 175 (08) :5260-5268

[42] A 46-NUCLEOTIDE PROMOTER SEGMENT FROM AN IFN-ALPHA GENE RENDERS AN UNRELATED PROMOTER INDUCIBLE BY VIRUS [J].

RYALS, J ;

DIERKS, P ;

RAGG, H ;

WEISSMANN, C .

CELL, 1985, 41 (02) :497-507

[43] Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2 [J].

Saito, Takeshi ;

Hirai, Reiko ;

Loo, Yueh-Ming ;

Owen, David ;

Johnson, Cynthia L. ;

Sinha, Sangita C. ;

Akira, Shizuo ;

Fujita, Takashi ;

Gale, Michael, Jr. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (02) :582-587

[44] Antiviral actions of interferons [J].

Samuel, CE .

CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (04) :778-809

[45] Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-β gene [J].

Sato, M ;

Tanaka, N ;

Hata, N ;

Oda, E ;

Taniguchi, T .

FEBS LETTERS, 1998, 425 (01) :112-116

[46] Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7 [J].

Sato, M ;

Hata, N ;

Asagiri, M ;

Nakaya, T ;

Taniguchi, T ;

Tanaka, N .

FEBS LETTERS, 1998, 441 (01) :106-110

[47] Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3 [J].

Seth, RB ;

Sun, LJ ;

Ea, CK ;

Chen, ZJJ .

CELL, 2005, 122 (05) :669-682

[48] Triggering the interferon antiviral response through an IKK-related pathway [J].

Sharma, S ;

tenOever, BR ;

Grandvaux, N ;

Zhou, GP ;

Lin, RT ;

Hiscott, J .

SCIENCE, 2003, 300 (5622) :1148-1151

[49] IL-28, IL-29 and their class II cytokine receptor IL-28R [J].

Sheppard, P ;

Kindsvogel, W ;

Xu, WF ;

Henderson, K ;

Schlutsmeyer, S ;

Whitmore, TE ;

Kuestner, R ;

Garrigues, U ;

Birks, C ;

Roraback, J ;

Ostrander, C ;

Dong, D ;

Shin, J ;

Presnell, S ;

Fox, B ;

Haldeman, B ;

Cooper, E ;

Taft, D ;

Gilbert, T ;

Grant, FJ ;

Tackett, M ;

Krivan, W ;

McKnight, G ;

Clegg, C ;

Foster, D ;

Klucher, KM .

NATURE IMMUNOLOGY, 2003, 4 (01) :63-68

[50] The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExX-box helicase to direct RNAi in C-elegans [J].

Tabara, H ;

Yigit, E ;

Siomi, H ;

Mello, CC .

CELL, 2002, 109 (07) :861-871

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