Making recombinant proteins in animals - different systems, different applications

被引：89

作者：

Dyck, MK ^{[1
]}

Lacroix, D ^{[1
]}

Pothier, F ^{[1
]}

Sirard, MA ^{[1
]}

机构：

[1] Univ Laval, Ctr Rech Biol Reprod, Dept Anim Sci, Ste Foy, PQ G1K 7P4, Canada

来源：

TRENDS IN BIOTECHNOLOGY | 2003年 / 21卷 / 09期

关键词：

D O I：

10.1016/S0167-7799(03)00190-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Transgenic animal bioreactors represent a powerful tool to address the growing need for therapeutic recombinant proteins. The ability of transgenic animals to produce complex, biologically active recombinant proteins in an efficient and economic manner has stimulated a great deal of interest in this area. As a result, genetically modified animals of several species, expressing foreign proteins in various tissues, are currently being developed. However, the generation of transgenic animals is a cumbersome process and remains problematic in the application of this technology. The advantages and disadvantages of different transgenic systems in relation to other bioreactor systems are discussed.

引用

页码：394 / 399

页数：6

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