Structure and mechanism of DNA polymerases

被引：179

作者：

Rothwell, PJ ^{[1
]}

Waksman, G ^{[1
]}

机构：

[1] Univ London & Birkbeck Coll, Inst Struct Mol Biol, London WC1E 7HX, England

来源：

FIBROUS PROTEINS: MUSCLE AND MOLECULAR MOTORS | 2005年 / 71卷

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0065-3233(04)71011-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA polymerases are molecular motors directing the synthesis of DNA from nucleotides. All polymerases have a common architectural framework consisting of three canonical subdomains termed the fingers, palm, and thumb subdomains. Kinetically, they cycle through various states corresponding to conformational transitions, which may or may not generate force. In this review, we present and discuss the kinetic, structural, and single-molecule works that have contributed to our understanding of DNA polymerase function.

引用

页码：401 / +

页数：44

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