Palladium-Catalyzed Sequential Formation of C-C Bonds: Efficient Assembly of 2-Substituted and 2,3-Disubstituted Quinolines

被引：100

作者：

Ji, Xiaochen ^{[1
]}

Huang, Huawen ^{[1
]}

Li, Yibiao ^{[1
]}

Chen, Huoji ^{[1
]}

Jiang, Huanfeng ^{[1
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 29期

基金：

中国国家自然科学基金;

关键词：

C?C bond formation; oxidation; palladium; quinolines; 3-COMPONENT POVAROV REACTION; ARENE CARBOXYLIC-ACIDS; SUBSTITUTED QUINOLINES; DECARBOXYLATIVE OLEFINATION; HETEROAROMATIC-COMPOUNDS; BIOLOGICAL EVALUATION; ANTIBACTERIAL AGENTS; MOLECULAR-OXYGEN; DIRECT ARYLATION; AROMATIC-AMINES;

D O I：

10.1002/anie.201202412

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of substituted quinolines was prepared from arylamines, aldehydes, and terminal olefins (see scheme). The palladium-catalyzed sequential formation of C-C bonds proceeds smoothly with both electron-deficient and electron-rich olefins. When acrylic acid is used as terminal olefin, decarboxylation occurs to provide 2-substituted quinolines. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7292 / 7296

页数：5

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