Solid-phase synthesis of 2,6,8-trisubstituted purines

被引：31

作者：

Brill, WKD ^{[1
]}

Riva-Toniolo, C ^{[1
]}

机构：

[1] Novartis Pharma AG, Combinatorial Chem Unit, CH-4056 Basel, Switzerland

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 37期

关键词：

D O I：

10.1016/S0040-4039(01)01300-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,6,8-Trisubstituted purines were synthesized from 2,6-dichloropurine bound to polystyrene-based Rink resin at the N(9) position. Selective successive displacements of the chlorine atoms in the 2- and 6-positions followed. Bromination of C(8) and Stille coupling concluded the synthesis. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：6515 / 6518

页数：4

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