Biased excitable networks: how cells direct motion in response to gradients

被引：101

作者：

Iglesias, Pablo A. ^{[1
]}

Devreotes, Peter N. ^{[2
]}

机构：

[1] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA

[2] Johns Hopkins Sch Med, Dept Cell Biol, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2012年 / 24卷 / 02期

基金：

美国国家卫生研究院;

关键词：

REACTION-DIFFUSION WAVES; PSEUDOPODIUM EXTENSION; EUKARYOTIC CHEMOTAXIS; ACTIN; LOCOMOTION; MODELS; OSCILLATIONS; ORGANIZATION; ACTIVATION; MOTILITY;

D O I：

10.1016/j.ceb.2011.11.009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The actin cytoskeleton in motile cells has many of the hallmarks of an excitable medium, including the presence of propagating waves. This excitable behavior can account for the spontaneous migration of cells. A number of reports have suggested that the chemoattractant-mediated signaling can bias excitability, thus providing a means by which cell motility can be directed. In this review, we discuss some of these observations and theories proposed to explain them. We also suggest a mechanism for cell polarity that can be incorporated into the existing framework.

引用

页码：245 / 253

页数：9

共 46 条

[1] Self-organization of the phosphatidylinositol lipids signaling system for random cell migration [J].

Arai, Yoshiyuki ;

Shibata, Tatsuo ;

Matsuoka, Satomi ;

Sato, Masayuki J. ;

Yanagida, Toshio ;

Ueda, Masahiro .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (27) :12399-12404

[2] Correlated Waves of Actin Filaments and PIP3 in Dictyostelium Cells [J].

Asano, Yukako ;

Nagasaki, Akira ;

Uyeda, Taro Q. P. .

CELL MOTILITY AND THE CYTOSKELETON, 2008, 65 (12) :923-934

[3] Quantitative analysis of random ameboid motion [J].

Boedeker, H. U. ;

Beta, C. ;

Frank, T. D. ;

Bodenschatz, E. .

EPL, 2010, 90 (02)

[4] The Ordered Extension of Pseudopodia by Amoeboid Cells in the Absence of External Cues [J].

Bosgraaf, Leonard ;

Van Haastert, Peter J. M. .

PLOS ONE, 2009, 4 (04)

[5] Dynamic actin patterns and Arp2/3 assembly at the substrate-attached surface of motile cells [J].

Bretschneider, T ;

Diez, S ;

Anderson, K ;

Heuser, J ;

Clarke, M ;

Müller-Taubenberger, A ;

Köhler, J ;

Gerisch, G .

CURRENT BIOLOGY, 2004, 14 (01) :1-10

[6] Dynamic organization of the actin system in the motile cells of Dictyostelium [J].

Bretschneider, T ;

Jonkman, J ;

Köhler, J ;

Medalia, O ;

Barisic, K ;

Weber, I ;

Stelzer, EHK ;

Baumeister, W ;

Gerisch, G .

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 2002, 23 (7-8) :639-649

[7] The Three-Dimensional Dynamics of Actin Waves, a Model of Cytoskeletal Self-Organization [J].

Bretschneider, Till ;

Anderson, Kurt ;

Ecke, Mary ;

Mueller-Taubenberger, Annette ;

Schroth-Diez, Britta ;

Ishikawa-Ankerhold, Hellen C. ;

Gerisch, Guenther .

BIOPHYSICAL JOURNAL, 2009, 96 (07) :2888-2900

[8]

Cai H, 2011, SEM CELL DE IN PRESS, DOI [101016/j.semcdb.201107.02, DOI 10.1016/J.SEMCDB.2011.07.02]

[9] Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis [J].

Cai, Huaqing ;

Das, Satarupa ;

Kamimura, Yoichiro ;

Long, Yu ;

Parent, Carole A. ;

Devreotes, Peter N. .

JOURNAL OF CELL BIOLOGY, 2010, 190 (02) :233-245

[10] Dendritic Actin Filament Nucleation Causes Traveling Waves and Patches [J].

Carlsson, Anders E. .

PHYSICAL REVIEW LETTERS, 2010, 104 (22)

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