Neurofibrillary changes of the Alzheimer type in very elderly individuals: Neither inevitable nor benign - Commentary on "no disease in the brain of a 115-year-old woman"

被引:19
作者
Del Tredici, Kelly [1 ]
Braak, Heiko [1 ]
机构
[1] Inst Clin Neuroanat, D-60590 Frankfurt, Germany
关键词
aging; centenarians; neurofibrillary tangles; neuropil threads; staging; supercentenarians;
D O I
10.1016/j.neurobiolaging.2008.04.016
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
引用
收藏
页码:1133 / 1136
页数:4
相关论文
共 42 条
[1]   Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain [J].
Arendt, T ;
Brückner, MK ;
Gertz, HJ ;
Marcova, L .
NEUROSCIENCE, 1998, 83 (04) :991-1002
[2]   NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE [J].
ARRIAGADA, PV ;
GROWDON, JH ;
HEDLEYWHYTE, ET ;
HYMAN, BT .
NEUROLOGY, 1992, 42 (03) :631-639
[3]  
Braak H, 2003, MILD COGNITIVE IMPAIRMENT: AGING TO ALZHEIMER'S DISEASE, P149
[4]   STAGING OF ALZHEIMERS-DISEASE-RELATED NEUROFIBRILLARY CHANGES [J].
BRAAK, H ;
BRAAK, E .
NEUROBIOLOGY OF AGING, 1995, 16 (03) :271-278
[5]   Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis [J].
Braak, H ;
Braak, E .
ACTA NEUROPATHOLOGICA, 1996, 92 (02) :197-201
[6]   Frequency of stages of Alzheimer-related lesions in different age categories [J].
Braak, H ;
Braak, E .
NEUROBIOLOGY OF AGING, 1997, 18 (04) :351-357
[7]   NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].
BRAAK, H ;
BRAAK, E .
ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259
[8]   Staging of cortical neurofibrillary inclusions of the Alzheimer's type [J].
Braak, Heiko ;
Del Tredici, Kelly .
ALZHEIMER: 100 YEARS AND BEYOND, 2006, :97-+
[9]   Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry [J].
Braak, Heiko ;
Alafuzoff, Irina ;
Arzberger, Thomas ;
Kretzschmar, Hans ;
Del Tredici, Kelly .
ACTA NEUROPATHOLOGICA, 2006, 112 (04) :389-404
[10]   PRELIMINARY EVIDENCE - DECREASED GAP-43 MESSAGE IN TANGLE-BEARING NEURONS RELATIVE TO ADJACENT TANGLE-FREE NEURONS IN ALZHEIMERS-DISEASE PARAHIPPOCAMPAL GYRUS [J].
CALLAHAN, LM ;
SELSKI, DJ ;
MARTZEN, MR ;
CHEETHAM, JE ;
COLEMAN, PD .
NEUROBIOLOGY OF AGING, 1994, 15 (03) :381-386