Immune cell signaling defects in lupus: activation, anergy and death

被引：103

作者：

Tsokos, GC

Liossis, SNC

机构：

[1] Uniformed Serv Univ Hlth Sci, Dept Med, Div Rheumatol & Immunol, Bethesda, MD 20814 USA

[2] Walter Reed Army Med Ctr, Dept Clin Physiol, Washington, DC 20307 USA

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 03期

关键词：

D O I：

10.1016/S0167-5699(98)01395-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have identified novel aberrations in antigen receptor-mediated signaling events in lymphocytes from patients with systemic lupus erythematosus. Here, we propose that in lupus lymphocytes, the receptor-mediated increase in protein tyrosine phosphorylation and cytoplasmic free Ca2+ responses, along with T-cell receptor zeta chain deficiency, might explain the previously described diverse and conflicting immunoregulatory defects in human lupus.

引用

页码：119 / 124

页数：6

共 42 条

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