Synthesis of the integrastatin nucleus using the Ramberg-Bilcklund reaction

被引：31

作者：

Foot, JS ^{[1
]}

Giblin, GMP

Taylor, RJK

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[2] GlaxoSmithKline, Dept Med Chem Neurol, Welwyn Garden City AL6 9AR, Herts, England

[3] GlaxoSmithKline, GI CEDD, Welwyn Garden City AL6 9AR, Herts, England

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 23期

关键词：

D O I：

10.1021/ol035786v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of the tetracyclic nucleus of the Integrastatins, natural products that have been shown to selectively inhibit HIV-1 integrase, is reported. Key steps of this synthesis involve a novel cis-selective Ramberg-Backlund reaction and an unusual Lewis acid-promoted cyclization step.

引用

页码：4441 / 4444

页数：4

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