Rhodanine derivatives as inhibitors of JS']JSP-1

被引：169

作者：

Cutshall, NS ^{[1
]}

O'Day, C ^{[1
]}

Prezhdo, M ^{[1
]}

机构：

[1] Ceptyr Inc, Bothell, WA 98021 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 14期

关键词：

rhodanine; PTP; DSP;

D O I：

10.1016/j.bmcl.2005.05.034

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：3374 / 3379

页数：6

相关论文

共 26 条

[1] Protein tyrosine phosphatases in the human genome [J].

Alonso, A ;

Sasin, J ;

Bottini, N ;

Friedberg, I ;

Friedberg, I ;

Osterman, A ;

Godzik, A ;

Hunter, T ;

Dixon, J ;

Mustelin, T .

CELL, 2004, 117 (06) :699-711

[2] STUDIES IN THE CYANINE DYE SERIES .11. THE MEROCYANINES [J].

BROOKER, LGS ;

KEYES, GH ;

SPRAGUE, RH ;

VANDYKE, RH ;

VANLARE, E ;

VANZANDT, G ;

WHITE, FL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1951, 73 (11) :5326-5332

[3] Synthesis and aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones [J].

Bruno, G ;

Costantino, L ;

Curinga, C ;

Maccari, R ;

Monforte, F ;

Nicolò, F ;

Ottanà, R ;

Vigorita, MG .

BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (04) :1077-1084

[4] SYNTHESIS AND NMR-STUDIES OF CHIRAL 4-OXAZOLIDINONES AND RHODANINES [J].

DOGAN, I ;

BURGEMEISTER, T ;

ICLI, S ;

MANNSCHRECK, A .

TETRAHEDRON, 1992, 48 (35) :7157-7164

[5] S-GLUCOSYLATED HYDANTOINS AS NEW ANTIVIRAL AGENTS [J].

ELBARBARY, AA ;

KHODAIR, AI ;

PEDERSEN, EB ;

NIELSEN, C .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (01) :73-77

[6] MECHANISM OF INHIBITION OF HISTIDINE DECARBOXYLASE BY RHODANINES [J].

FREE, CA ;

MAJCHROWICZ, E ;

HESS, SM .

BIOCHEMICAL PHARMACOLOGY, 1971, 20 (07) :1421-+

[7] Synthesis, activity, and molecular modeling of new 2,4-dioxo-5-(naphthylmethylene)-3-thiazolidineacetic acids and 2-thioxo analogues as potent aldose reductase inhibitors [J].

Fresneau, P ;

Cussac, M ;

Morand, JM ;

Szymonski, B ;

Tranqui, D ;

Leclerc, G .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (24) :4706-4715

[8] Improvement of corneal fluorescein staining in post cataract surgery of diabetic patients by an oral aldose reductase inhibitor, ONO-2235 [J].

Fujishima, H ;

Tsubota, K .

BRITISH JOURNAL OF OPHTHALMOLOGY, 2002, 86 (08) :860-863

[9] Examination of novel non-phosphorus-containing phosphotyrosyl mimetics against protein-tyrosine phosphatase-1B and demonstration of differential affinities toward Grb2 SH2 domains [J].

Gao, Y ;

Wu, L ;

Luo, JH ;

Guo, R ;

Yang, D ;

Zhang, ZY ;

Burke, TR .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (09) :923-927

[10] Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-malollyl)phenylalanine as a potent phosphotyrosyl mimetic [J].

Gao, Y ;

Luo, J ;

Yao, ZJ ;

Guo, RB ;

Zou, H ;

Kelley, J ;

Voigt, JH ;

Yang, DJ ;

Burke, TR .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (05) :911-920