Rhodanine derivatives as inhibitors of JS']JSP-1

被引：169

作者：

Cutshall, NS ^{[1
]}

O'Day, C ^{[1
]}

Prezhdo, M ^{[1
]}

机构：

[1] Ceptyr Inc, Bothell, WA 98021 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 14期

关键词：

rhodanine; PTP; DSP;

D O I：

10.1016/j.bmcl.2005.05.034

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3374 / 3379

页数：6

共 26 条

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[22] Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JS']JSP-1 [J].