Rhodanine derivatives as inhibitors of JS']JSP-1

被引：169

作者：

Cutshall, NS ^{[1
]}

O'Day, C ^{[1
]}

Prezhdo, M ^{[1
]}

机构：

[1] Ceptyr Inc, Bothell, WA 98021 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 14期

关键词：

rhodanine; PTP; DSP;

D O I：

10.1016/j.bmcl.2005.05.034

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：3374 / 3379

页数：6

相关论文

共 26 条

[11] Regiospecific reduction of 5-benzylidene-2,4-thiazolidinediones and 4-oxo-2-thiazolidinethiones using lithium borohydride in pyridine and tetrahydrofuran [J].

Giles, RG ;

Lewis, NJ ;

Quick, JK ;

Sasse, MJ ;

Urquhart, MWJ ;

Youssef, L .

TETRAHEDRON, 2000, 56 (26) :4531-4537

[12] The synthesis and SAR of rhodanines as novel class C β-lactamase inhibitors [J].

Grant, EB ;

Guiadeen, D ;

Baum, EZ ;

Foleno, BD ;

Jin, HY ;

Montenegro, DA ;

Nelson, EA ;

Bush, K ;

Hlasta, DJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (19) :2179-2182

[13] Protein tyrosine phosphatases: Strategies for distinguishing proteins in a family containing multiple drug targets and anti-targets [J].

Hoffman, BT ;

Nelson, MR ;

Burdick, K ;

Baxter, SM .

CURRENT PHARMACEUTICAL DESIGN, 2004, 10 (10) :1161-1181

[14] SAR and X-ray.: A new approach combining fragment-based screening and rational drug design:: Application to the discovery of nanomolar inhibitors of Src SH2 [J].

Lesuisse, D ;

Lange, G ;

Deprez, P ;

Bénard, D ;

Schoot, B ;

Delettre, G ;

Marquette, JP ;

Broto, P ;

Jean-Baptiste, V ;

Bichet, P ;

Sarubbi, E ;

Mandine, E .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (12) :2379-2387

[15] The difluoromethylenesulfonic acid group as a monoanionic phosphate surrogate for obtaining PTP1B inhibitors [J].

Leung, C ;

Grzyb, J ;

Lee, J ;

Meyer, N ;

Hum, G ;

Jia, CG ;

Liu, SF ;

Taylor, SD .

BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (07) :2309-2323

[16]

MARCH J, 1992, ADV ORG CHEM, P17

[17]

MOMOSE Y, 1991, Chemical and Pharmaceutical Bulletin (Tokyo), V39, P1440

[18] ON THE REACTIVITY OF THE EXOCYCLIC DOUBLE BOND IN 5-ARYLIDENE-3-ARYL-2,4-THIAZOLIDINEDIONES - THEIR REACTION WITH DIAZOALKANES, PARA-THIOCRESOL AND PIPERIDINE [J].

MUSTAFA, A ;

ASKER, W ;

ELDINSOBHY, ME .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1960, 82 (10) :2597-2601

[19] STUDIES ON FUNGICIDES .24. REACTION OF 5-METHOXYCARBONYL-METHYLIDENE-2-THIOXO(OR OXO)-4-THIAZOLIDONES WITH ORTHO-AMINOBENZENETHIOL AND OTHER THIOLS [J].

NAGASE, H .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1974, 22 (01) :42-49

[20]

OHISHI Y, 1992, CHEM PHARM BULL, V40, P907