Nuclear gene transcription and chromatin in Trypanosoma brucei

被引：19

作者：

Horn, D ^{[1
]}

机构：

[1] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2001年 / 31卷 / 11期

基金：

英国惠康基金;

关键词：

transcription; Trypanosoma brucei; VSG;

D O I：

10.1016/S0020-7519(01)00264-8

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

As in other eucaryotes, the nuclear genome in Trypanosoma brucei is organised into silent domains and active domains transcribed by distinct RNA polymerases. The basic mechanisms underlying eucaryotic gene transcription are conserved between humans and yeast, and understood in some detail in these cells, Meanwhile, relatively little is known about the transcription machinery, the chromatin templates or their interactions in trypanosomatids. Here. I discuss and compare nuclear gene transcription in T. brucei with transcription in other eucaryotes focusing in particular on mono-allelic transcription of genes that encode the variant surface glycoproteins. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1157 / 1165

页数：9

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