Peptoids as source of compounds eliciting antibacterial activity

被引：25

作者：

Masip, I ^{[1
]}

Pérez-Paya, E ^{[1
]}

Messeguer, A ^{[1
]}

机构：

[1] CSIC, IIQAB, Dept Biol Organ Chem, E-08034 Barcelona, Spain

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2005年 / 8卷 / 03期

关键词：

N-alkylglycine trimers; peptoids; combinatorial chemistry; chemical libraries; antibacterial activity; bacterial resistance;

D O I：

10.2174/1386207053764567

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

N-Alkylglycine oligomers (peptoids) constitute a family of non-natural peptidomimetics attractive for the early drug discovery process because of their physicochemical features, easy of adaptation to combinatorial chemistry approaches and their proteolytic stability. Consequently, peptoid libraries have found application for discovering hits against a wide diversity of pharmaceutical targets, among which different examples of antibacterials are found. In the present work, research efforts addressed towards the identification of peptoids as antibacterial agents are discussed.

引用

页码：235 / 239

页数：5

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