MicroRNA with a MacroFunction

被引:37
作者
Rane, Shweta [1 ]
Sayed, Danish [1 ]
Abdellatif, Maha [1 ]
机构
[1] Univ Med & Dent New Jersey, Cardiovasc Res Inst, Dept Cell Biol & Mol Med, Newark, NJ 07103 USA
关键词
microRNA; miRNA; post-transcriptional; biomarkers; cardiac hypertrophy; cancer;
D O I
10.4161/cc.6.15.4551
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
With the advent of microRNA ( miRNA) we are compelled to revise our understanding of the mechanisms underlying gene regulation during health and disease. A miRNA is similar to 21 ribonucleotides-long, genetically encoded, with a potential to recognize multiple mRNA targets guided by sequence complementarity and RNA-binding proteins. This class of molecules is functionally versatile, with the capacity to specifically inhibit translation initiation or elongation, as well as, induce mRNA degradation, through predominantly targeting the 3'-untranslated regions of mRNA. Early on it was realized that the levels of individual miRNA varied under different developmental, biological, or pathological conditions, thus, implicating these molecules in normal and pathological cellular attributes. In this article we will share our views on how the functions of miRNA conform to our existing knowledge on post-transcriptional regulation of gene expression and disease mechanisms, and their potential as biomarkers and therapeutic targets in diseases.
引用
收藏
页码:1850 / 1855
页数:6
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