Iron-sulphur clusters as genetic regulatory switches: The bifunctional iron regulatory protein-1

被引：61

作者：

Paraskeva, E ^{[1
]}

Hentze, MW ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB, GENE EXPRESS PROGRAMME, D-69117 HEIDELBERG, GERMANY

来源：

FEBS LETTERS | 1996年 / 389卷 / 01期

关键词：

iron responsive element; aconitase; iron metabolism; RNA/protein interactions;

D O I：

10.1016/0014-5793(96)00574-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the eighties, iron regulatory protein-1 (IRP-1) was identified as a cytoplasmic mRNA-binding protein that regulates vertebrate cell iron metabolism. More recently, IRP-1 was found to represent the functional cytoplasmic homologue of mitochondrial aconitase, a citric acid cycle enzyme. Its two functions are mutually exclusive and depend on the status of an Fe-S cluster: the (cluster-less) apoIRP-1 binds to RNA, while the incorporation of a cubane 4Fe-4S cluster is required for enzymatic activity. Cellular signals including iron levels, nitric oxide and oxidative stress can regulate between the two activities posttranslationally and reversibly via the EPS cluster, Recent reports suggest that other regulatory proteins may be controlled by similar mechanisms.

引用

页码：40 / 43

页数：4

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