Synthesis of phosphino oxazoline ligand libraries from amino acid and phosphino carboxylate building blocks

被引：72

作者：

Gilbertson, SR ^{[1
]}

Chang, CWT ^{[1
]}

机构：

[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 23期

关键词：

D O I：

10.1021/jo981420y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modular route to new phosphine-oxazoline ligands is reported. The ability of these ligands to asymmetrically catalyze the addition of dimethyl malonate to 1,3-diphenylprop-2-enyl acetate was investigated. The best of these Ligands gave a palladium complex which catalyzed the addition of dimethyl malonate to 1,3-diphenylprop-2-enyl acetate in a 99% yield and in 98% enantiomeric excess (Table 3, entry 11).

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页码：8424 / 8431

页数：8

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