Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes

被引：232

作者：

Hai, Rong ^{[1
]}

Krammer, Florian ^{[1
]}

Tan, Gene S. ^{[1
]}

Pica, Natalie ^{[1
]}

Eggink, Dirk ^{[1
]}

Maamary, Jad ^{[1
]}

Margine, Irina ^{[1
]}

Albrecht, Randy A. ^{[1
,2
]}

Palese, Peter ^{[1
,3
]}

机构：

[1] Mt Sinai Sch Med, Dept Microbiol, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Global Hlth & Emerging Pathogens Inst, New York, NY USA

[3] Mt Sinai Sch Med, Dept Med, New York, NY USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 10期

基金：

奥地利科学基金会; 美国国家卫生研究院;

关键词：

A VIRUSES; ANTIBODIES; GENERATION; PROTEIN; TYPE-1; CELLS; ENTRY;

D O I：

10.1128/JVI.00137-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The influenza virus hemagglutinin molecule possesses a globular head domain that mediates receptor binding and a stalk domain at the membrane-proximal region. We generated functional influenza viruses expressing chimeric hemagglutinins encompassing a variety of globular head and stalk combinations, not only from different hemagglutinin subtypes but also from different hemagglutinin phylogenetic groups. These chimeric recombinant viruses possess growth properties similar to those of wildtype influenza viruses and can be used as reagents to measure domain-specific antibodies in virological and immunological assays.

引用

页码：5774 / 5781

页数：8

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