The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations

被引：398

作者：

Leach, MO

Brindle, KM

Evelhoch, JL

Griffiths, JR

Horsman, MR

Jackson, A

Jayson, GC

Judson, IR

Knopp, MV

Maxwell, RJ

McIntyre, D

Padhani, AR

Price, P

Rathbone, R

Rustin, GJ

Tofts, PS

Tozer, GM

Vennart, W

Waterton, JC

Williams, SR

Workmanw, P

机构：

[1] Royal Marsden Hosp, Inst Canc Res, Canc Res UK Clin Magnet Resonance Res Grp, Sutton SM2 5PT, Surrey, England

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[3] Amgen Inc, Thousand Oaks, CA 91320 USA

[4] St George Hosp, Sch Med, Dept Basic Med Sci, London SW17 0RE, England

[5] Aarhus Univ Hosp, Dept Expt Clin Oncol, DK-8000 Aarhus, Denmark

[6] Univ Manchester, Manchester M13 9PT, Lancs, England

[7] Christie Hosp, Canc Res UK Dept Med Oncol, Manchester M20 4BX, Lancs, England

[8] Inst Canc Res, Canc Res UK Ctr Canc Therapeut, Sutton SM2 5NG, Surrey, England

[9] Ohio State Univ, Med Ctr, Dept Radiol, Columbus, OH 43210 USA

[10] Mt Vernon Hosp, Gray Canc Inst, Tumor Microcirculat Grp, Northwood HA6 2JR, Middx, England

[11] St George Hosp, Sch Med, Canc Res UK Biomed MR Grp, London SW17 0RE, England

[12] Mt Vernon Hosp, Paul Strickland Scanner Ctr, Northwood HA6 2RN, Middx, England

[13] Univ Manchester, Manchester Mol Imaging Ctr, Manchester M20 3LJ, Lancs, England

[14] Canc Res UK, Drug Dev Off, London, England

[15] Mt Vernon Canc Ctr, Dept Med Oncol, Northwood, Middx, England

[16] UCL, Inst Neurol, NMR Res Unit, London WC1N 3BG, England

[17] Pfizer Ltd, Cent Res Dept ECRG C746, Sandwich CT13 9NJ, Kent, England

[18] AstraZeneca, Global Sci & Informat, Macclesfield SK10 4TG, Cheshire, England

[19] Inst Canc Res, Haddow Labs, Canc Res UK Ctr Canc Therapeut, Sutton SM2 5NG, Surrey, England

来源：

BRITISH JOURNAL OF CANCER | 2005年 / 92卷 / 09期

关键词：

biomarker; magnetic resonance; therapeutic trials; antiangiogenic; antivascular; cancer therapy;

D O I：

10.1038/sj.bjc.6602550

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome of a workshop that considered the methodology and design of magnetic resonance studies, recommending how this new tool might best be used.

引用

页码：1599 / 1610

页数：12

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