Mechanisms of sodium channel inactivation

被引：193

作者：

Goldin, AL ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(03)00065-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rapid inactivation of sodium channels is crucial for the normal electrical activity of excitable cells. There are many different types of inactivation, including fast, slow and ultra-slow, and each of these can be modulated by cellular factors or accessory subunits. Fast inactivation occurs by a 'hinged lid' mechanism in which an inactivating particle occludes the pore, whereas slow inactivation is most likely to involve a rearrangement of the channel pore. Subtle defects in either inactivation process can lead to debilitating human diseases, including periodic paralyses in muscle, ventricular fibrillation and long QT syndrome (delayed cardiac repolarization) in the heart, and epilepsy in the CNS.

引用

页码：284 / 290

页数：7

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