Agonist concentration gradients as a generalizable regulatory implementation strategy

被引：28

作者：

Calabrese, EJ ^{[1
]}

Baldwin, LA ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA

来源：

CRITICAL REVIEWS IN TOXICOLOGY | 2001年 / 31卷 / 4-5期

关键词：

hormesis; U shaped; biphasic; stimulatory; inhibitory; dose response; receptor mediated;

D O I：

10.1080/20014091111758

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

This article proposes a general mechanism by which biphasic dose-response relationships occur in pharmacological and toxicological experimental systems. Such biphasic responses are mediated via a strategy of differential binding to stimulatory and inhibitory receptor subtypes based on agonist concentrations. Such a strategy is widely seen in pharmacological systems and has been demonstrated in toxicological-related biphasic dose responses in which the treatment altered levels of endogenous agonists.

引用

页码：471 / 473

页数：3

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