And now introducing mammalian mirtrons

被引:28
作者
Chan, Shih-Peng [1 ]
Slack, Frank J. [1 ]
机构
[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
关键词
BIOGENESIS; MICRORNAS; RNAS;
D O I
10.1016/j.devcel.2007.10.010
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Mirtrons are short hairpin introns recently found in flies and nematodes that provide an alternative source for animal microRNA biogenesis and use the splicing machinery to bypass Drosha cleavage in initial maturation. The presence of mirtrons outside of invertebrates was not previously known. In the October 26 issue of Molecular Cell, Berezikov et al. expose a number of short mammalian introns as mirtrons.
引用
收藏
页码:605 / 607
页数:3
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