Nanoplatforms for targeted molecular imaging in living subjects

被引:448
作者
Cai, Weibo [1 ]
Chen, Xiaoyuan [1 ]
机构
[1] Stanford Univ, Dept Radiol & Bio X Program, MIPS, Stanford, CA 94305 USA
关键词
cancer; molecular imaging; nanomedicine; nanoplatforms; nanotechnology;
D O I
10.1002/smll.200700351
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Molecular or personalized medicine is the future of patient management and molecular imaging plays a key role towards this goal. Recently, nanoplatform-based molecular imaging has emerged as an interdisciplinary field, which involves chemistry, engineering, biology, and medicine. Possessing unprecedented potential for early detection, accurate diagnosis, and personalized treatment of diseases, nanoplatforms have been employed in every single biomedical imaging modality, namely, optical imaging, computed tomography, ultrasound, magnetic resonance imaging, singlephoton-emission computed tomography, and positron emission tomography. Multifunctionality is the key advantage of nanoplatforms over traditional approaches. Targeting ligands, imaging labels, therapeutic drugs, and many other agents can all be integrated into the nanoplatform to allow for targeted molecular imaging and molecular therapy by encompassing many biological and biophysical barriers. In this Review, we will summarize the current stateof-the-art of nanoplatforms for targeted molecular imaging in living subjects.
引用
收藏
页码:1840 / 1854
页数:15
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