lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs

被引：453

作者：

Quek, Xiu Cheng ^{[1
,2
]}

Thomson, Daniel W. ^{[1
]}

Maag, Jesper L. V. ^{[1
,2
]}

Bartonicek, Nenad ^{[1
]}

Signal, Bethany ^{[1
]}

Clark, Michael B. ^{[1
,3
]}

Gloss, Brian S. ^{[1
,2
]}

Dinger, Marcel E. ^{[1
,2
]}

机构：

[1] Garvan Inst Med Res, Sydney, NSW 2010, Australia

[2] Univ New S Wales, St Vincents Clin Sch, Sydney, NSW 2052, Australia

[3] Univ Oxford, Dept Physiol Anat & Genet, MRC, Funct Genom Unit, Oxford OX1 3PT, England

来源：

NUCLEIC ACIDS RESEARCH | 2015年 / 43卷 / D1期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

INTEGRATIVE ANNOTATION; EXPRESSION; TRANSCRIPTION; EVOLUTION; SELECTION; REVEALS; GENCODE; GENOME; CERNA; GENE;

D O I：

10.1093/nar/gku988

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Despite the prevalence of long noncoding RNA (lncRNA) genes in eukaryotic genomes, only a small proportion have been examined for biological function. lncRNAdb, available at http://lncrnadb.org, provides users with a comprehensive, manually curated reference database of 287 eukaryotic lncRNAs that have been described independently in the scientific literature. In addition to capturing a great proportion of the recent literature describing functions for individual lncRNAs, lncRNAdb now offers an improved user interface enabling greater accessibility to sequence information, expression data and the literature. The new features in lncRNAdb include the integration of Illumina Body Atlas expression profiles, nucleotide sequence information, a BLAST search tool and easy export of content via direct download or a REST API. lncRNAdb is now endorsed by RNAcentral and is in compliance with the International Nucleotide Sequence Database Collaboration.

引用

页码：D168 / D173

页数：6

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