Hexarelin Signaling to PPARγ in Metabolic Diseases

被引：17

作者：

Demers, Annie ^{[1
]}

Rodrigue-Way, Amelie ^{[1
,2
]}

Tremblay, Andre ^{[1
,2
,3
]}

机构：

[1] Univ Montreal, Res Ctr, Ste Justine Hosp, Montreal, PQ H3T 1C5, Canada

[2] Univ Montreal, Dept Biochem, Montreal, PQ H3T 1J4, Canada

[3] Univ Montreal, Dept Obstet & Gynecol, Montreal, PQ H3T 1C5, Canada

来源：

PPAR RESEARCH | 2008年 / 2008卷

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1155/2008/364784

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Investigating the metabolic functions of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) has been extremely rewarding over the past years. Uncovering the biologic roles of PPAR gamma and its mechanism of action has greatly advanced our understanding of the transcriptional control of lipid and glucose metabolism, and compounds such as thiazolidinediones which directly regulate PPAR gamma have proven to exhibit potent insulin-sensitizer effects in the treatment of diabetes. We review here recent advances on the emerging role of growth hormone releasing peptides in regulating PPAR gamma through interaction with scavenger receptor CD36 and ghrelin GHS-R1a receptor. With the impact that these peptides exert on the metabolic pathways involved in lipid metabolism and energy homeostasis, it is hoped that the development of novel approaches in the regulation of PPAR functions will bring additional therapeutic possibilities to face problems related to metabolic diseases.

引用

页数：9

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