Laser scanning lithography for surface micropatterning on hydrogels

被引：70

作者：

Hahn, MS ^{[1
]}

Miller, JS ^{[1
]}

West, JL ^{[1
]}

机构：

[1] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

来源：

ADVANCED MATERIALS | 2005年 / 17卷 / 24期

关键词：

D O I：

10.1002/adma.200500184

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A versatile confocal-based laser scanning lithographic method for controlled, high-fidelity two-dimensional and three-dimensional surface patterning of deformable, solvated, photoactive substrates is presented (see Figure; scale bars represent 200 mu m). Patterned substrates functionalized with gradients of different cell-adhesive ligands can be fabricated, providing a tool for investigating cell-biomaterial interactions and the structure-function relationships of tissues.

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页码：2939 / +

页数：5

相关论文

共 23 条

[1] Geometric determinants of directional cell motility revealed using microcontact printing [J].

Brock, A ;

Chang, E ;

Ho, CC ;

LeDuc, P ;

Jiang, XY ;

Whitesides, GM ;

Ingber, DE .

LANGMUIR, 2003, 19 (05) :1611-1617

[2] Micropatterned surfaces for control of cell shape, position, and function [J].

Chen, CS ;

Mrksich, M ;

Huang, S ;

Whitesides, GM ;

Ingber, DE .

BIOTECHNOLOGY PROGRESS, 1998, 14 (03) :356-363

[3] Gradient micropattern immobilization of EGF to investigate the effect of artificial juxtacrine stimulation [J].

Chen, GP ;

Ito, YY .

BIOMATERIALS, 2001, 22 (18) :2453-2457

[4] Microfabricated devices in biotechnology and biochemical processing [J].

Chován, T ;

Guttman, A .

TRENDS IN BIOTECHNOLOGY, 2002, 20 (03) :116-122

[5] Patterned delivery of immunoglobulins to surfaces using microfluidic networks [J].

Delamarche, E ;

Bernard, A ;

Schmid, H ;

Michel, B ;

Biebuyck, H .

SCIENCE, 1997, 276 (5313) :779-781

[6] Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration [J].

DeLong, SA ;

Moon, JJ ;

West, JL .

BIOMATERIALS, 2005, 26 (16) :3227-3234

[7] Gradients of substrate-bound laminin orient axonal specification of neurons [J].

Dertinger, SKW ;

Jiang, XY ;

Li, ZY ;

Murthy, VN ;

Whitesides, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12542-12547

[8] Effects of synthetic micro- and nano-structured surfaces on cell behavior [J].

Flemming, RG ;

Murphy, CJ ;

Abrams, GA ;

Goodman, SL ;

Nealey, PF .

BIOMATERIALS, 1999, 20 (06) :573-588

[9] Near-field photolithography with a solid immersion lens [J].

Ghislain, LP ;

Elings, VB ;

Crozier, KB ;

Manalis, SR ;

Minne, SC ;

Wilder, K ;

Kino, GS ;

Quate, CF .

APPLIED PHYSICS LETTERS, 1999, 74 (04) :501-503

[10] PROTEIN ADSORPTION TO POLY(ETHYLENE OXIDE) SURFACES [J].

GOMBOTZ, WR ;

GUANGHUI, W ;

HORBETT, TA ;

HOFFMAN, AS .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1991, 25 (12) :1547-1562