Inhibition of β-amyloid cytotoxicity by midkine

被引：19

作者：

Yu, GSP ^{[1
]}

Hu, JG ^{[1
]}

Nakagawa, H ^{[1
]}

机构：

[1] BML, R&D Ctr, Kawagoe, Saitama 3501101, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 254卷 / 03期

关键词：

midkine; beta-amyloid protein; complex formation; aggregation; cytotoxicity; Alzheimer's disease;

D O I：

10.1016/S0304-3940(98)00685-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Midkine (MK) is a neurotrophic and angiogenic growth factor whose expression occurs mainly in fetus. It was reported that MK was present in senile plaques of Alzheimer's disease (AD). To investigate the role of MK during amyloid plaques formation in AD, we examined the in vitro effect of MK on A beta aggregation and A beta-induced cytotoxicity. We found that incubation of MK with A beta resulted in the formation of MK/A beta complexes. The C-terminus of MK (60-121) played a similar role as the full length MK in complex formation. This interaction of MK and A beta demonstrated significant inhibition on A beta self-aggregation. MK also inhibited the cytotoxicity of A beta on PC12h cells. These findings suggest that MK protects the cells from A beta-induced cytotoxicity through its complex formation with A beta. MK is probably expressed to prevent cell death in AD. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

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收藏

页码：125 / 128

页数：4

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