Preparation of redispersible dry emulsions by spray drying

被引:106
作者
Christensen, KL
Pedersen, GP
Kristensen, HG
机构
[1] Royal Danish Sch Pharm, Dept Pharmaceut, DK-2100 Copenhagen O, Denmark
[2] LEO Pharmaceut Prod, DK-2750 Ballerup, Denmark
关键词
spray drying; dry emulsion; lipid; hydroxypropylmethylcellulose (HPMC); microencapsulation; redispersibility;
D O I
10.1016/S0378-5173(00)00596-2
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Development of stable dry emulsions being able to reform the original o/w-emulsion by reconstitution in water is presented. Dry emulsions were prepared by spray drying liquid o/w-emulsions in a laboratory spray dryer. Three hydroxypropylmethylcellulose (HPMC) types were applied as solid carrier and emulsifier. The lipid phase was fractionated coconut oil. The ratio of solid carrier to lipid phase influenced the reconstitution properties. It was possible to prepare redispersible dry emulsions of a lipid content up to 40% dry powder mass. The different HPMC types had no noticeable effect on the reconstitution properties, but too viscous liquid o/w-emulsions were difficult to atomise. The type of rotary atomizer, or the rate of relation did not affect the technical properties of the dry emulsions containing 40% lipid. It was concluded that low viscosity HPMC was a useful solid carrier. The dry emulsions remained physically stable for at least 6 months. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:187 / 194
页数:8
相关论文
共 31 条
[11]   Optimisation of electrical conductance measurements for the quantification and prediction of phase separation in o/w-emulsions, containing hydroxypropylmethylcelluloses as emulsifying agents [J].
Kiekens, F ;
Vermeire, A ;
Samyn, N ;
Demeester, J ;
Remon, JP .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 146 (02) :239-245
[12]   USE OF SUPPORTS IN LYOPHILIZATION OF OIL-IN-WATER EMULSIONS [J].
LLADSER, M ;
MEDRANO, C ;
ARANCIBIA, A .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1968, 20 (06) :450-+
[13]   STUDIES ON DRUG MILK FREEZE-DRIED FORMULATIONS .1. BIOAVAILABILITY OF SULFAMETHIZOLE AND DICUMAROL FORMULATIONS [J].
MACHERAS, PE ;
REPPAS, CI .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1986, 75 (07) :692-696
[14]  
MASTERS K, 1991, SPRAY DRYING HDB, pCH6
[15]  
Molina C., 1995, STP PHARM PRATIQUES, V5, P63
[16]   SOLID-STATE EMULSIONS - THE EFFECTS OF MALTODEXTRIN ON MICROCRYSTALLINE AGING [J].
MYERS, SL ;
SHIVELY, ML .
PHARMACEUTICAL RESEARCH, 1993, 10 (09) :1389-1391
[17]   PREPARATION AND CHARACTERIZATION OF EMULSIFIABLE GLASSES - OIL-IN-WATER AND WATER-IN-OIL-IN-WATER EMULSIONS [J].
MYERS, SL ;
SHIVELY, ML .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1992, 149 (01) :271-278
[18]  
NAKAMOTO Y, 1975, CHEM PHARM BULL, V23, P3125
[19]   Solid state characterisation of a dry emulsion:: a potential drug delivery system [J].
Pedersen, GP ;
Fäldt, P ;
Bergenståhl, B ;
Kristensen, HG .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1998, 171 (02) :257-270
[20]   Evaluation of emulsifiable glasses for the oral administration of cyclosporin in beagle dogs [J].
Porter, CJH ;
Charman, SA ;
Williams, RD ;
Bakalova, MV ;
Charman, WN .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 141 (1-2) :227-237