Vanadium(III) chloride catalyzed Biginelli condensation:: solution phase library generation of dihydropyrimidin-(2H)-ones

被引：175

作者：

Sabitha, G ^{[1
]}

Reddy, GSKK ^{[1
]}

Reddy, KB ^{[1
]}

Yadav, JS ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 34期

关键词：

Biginelli condensation; VCl3; dihydropyrimidin-2(1H)ones; parallel synthesis;

D O I：

10.1016/S0040-4039(03)01564-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The three component condensation of an aldehyde, a beta-keto ester and urea (thiourea) in the presence of a catalytic amount of VCl3 is disclosed for the solution phase synthesis of dihydropyrimidinones. The ease of synthesis and work-up allowed the parallel synthesis of a 48-membered library of dihydropyrimidinones quickly and efficiently in good yields. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：6497 / 6499

页数：3

共 32 条

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