The ubiquitin-proteasome pathway: on protein death and cell life

被引:1159
作者
Ciechanover, A
机构
[1] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Dept Biochem, IL-31096 Haifa, Israel
[2] Technion Israel Inst Technol, Rappaport Family Inst Res Med Sci, IL-31096 Haifa, Israel
关键词
E1; E2; E3; pathogenesis; proteasome; protein degradation; ubiquitin;
D O I
10.1093/emboj/17.24.7151
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:7151 / 7160
页数:10
相关论文
共 72 条
  • [41] CONJUGATES OF UBIQUITIN CROSS-REACTIVE PROTEIN DISTRIBUTE IN A CYTOSKELETAL PATTERN
    LOEB, KR
    HAAS, AL
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (12) : 8408 - 8419
  • [42] A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
    Mahajan, R
    Delphin, C
    Guan, TL
    Gerace, L
    Melchior, F
    [J]. CELL, 1997, 88 (01) : 97 - 107
  • [43] Mayer RJ, 1996, ADV EXP MED BIOL, V389, P261
  • [44] Mechanisms of disease - Mechanisms of muscle wasting - The role of the ubiquitin-proteasome pathway
    Mitch, WE
    Goldberg, AL
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (25) : 1897 - 1905
  • [45] A protein conjugation system essential for autophagy
    Mizushima, N
    Noda, T
    Yoshimori, T
    Tanaka, Y
    Ishii, T
    George, MD
    Klionsky, DJ
    Ohsumi, M
    Ohsumi, Y
    [J]. NATURE, 1998, 395 (6700) : 395 - 398
  • [46] A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S-cerevisiae
    Moazed, D
    Johnson, AD
    [J]. CELL, 1996, 86 (04) : 667 - 677
  • [47] Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
    Musti, AM
    Treier, M
    Bohmann, D
    [J]. SCIENCE, 1997, 275 (5298) : 400 - 402
  • [48] THE 2ND-CODON RULE AND AUTOPHOSPHORYLATION GOVERN THE STABILITY AND ACTIVITY OF MOS DURING THE MEIOTIC CELL-CYCLE IN XENOPUS-OOCYTES
    NISHIZAWA, M
    OKAZAKI, K
    FURUNO, N
    WATANABE, N
    SAGATA, N
    [J]. EMBO JOURNAL, 1992, 11 (07) : 2433 - 2446
  • [49] The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice
    Perry, WL
    Hustad, CM
    Swing, DA
    O'Sullivan, TN
    Jenkins, NA
    Copeland, NG
    [J]. NATURE GENETICS, 1998, 18 (02) : 143 - 146
  • [50] PETERS JM, 1998, UBIQUITIN BIOL CELL, P1