Functionalized cyclopentadienyl titanium organometallic compounds as new antitumor drugs

被引：127

作者：

Allen, OR

Croll, L

Gott, AL

Knox, RJ

McGowan, PC

机构：

[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Enact Pharma PLC, Salisbury SP4 0JQ, Wilts, England

来源：

ORGANOMETALLICS | 2004年 / 23卷 / 02期

关键词：

D O I：

10.1021/om030403i

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A number of new ionic titanocene compounds have been isolated and characterized. These exhibit significant cytotoxicity against a number of different human tumor cell lines including a defined cisplatin-resistant cell line. One of the compounds is an order of magnitude more active than its nonfunctionalized equivalent.

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收藏

页码：288 / 292

页数：5

相关论文

共 16 条

[1] Synthesis and reactivity of Group 14 substituted amino-functionalised cyclopentadienyl compounds [J].

Bradley, S ;

Corradi, MM ;

Camm, KD ;

Furtado, SJ ;

McGowan, PC ;

Mumtaz, R ;

Thornton-Pett, M .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2002, 656 (1-2) :49-56

[2] Synthesis and structural studies of 1,1′-bis-amino-functionalized ferrocenes, ferrocene salts, and ferrocenium salts [J].

Bradley, S ;

Camm, KD ;

Liu, XM ;

McGowan, PC ;

Mumtaz, R ;

Oughton, KA ;

Podesta, TJ ;

Thornton-Pett, M .

INORGANIC CHEMISTRY, 2002, 41 (04) :715-726

[3] Synthesis and structure of amino-functionalized cyclopentadienyl vanadium complexes and evaluation of their butadiene polymerization behavior [J].

Bradley, S ;

Camm, KD ;

Furtado, SJ ;

Gott, AL ;

McGowan, PC ;

Podesta, TJ ;

Thornton-Pett, M .

ORGANOMETALLICS, 2002, 21 (16) :3443-3453

[4] Facile synthesis of amino-functionalised ferrocenes and vanadocenes [J].

Bradley, S ;

McGowan, PC ;

Oughton, KA ;

Thornton-Pett, M ;

Walsh, ME .

CHEMICAL COMMUNICATIONS, 1999, (01) :77-78

[5]

CARDOSO AM, 1980, J ORGANOMET CHEM, V186, P237

[6] Anti-proliferative activity and mechanism of action of titanocene dichloride [J].

Christodoulou, CV ;

Eliopoulos, AG ;

Young, LS ;

Hodgkins, L ;

Ferry, DR ;

Kerr, DJ .

BRITISH JOURNAL OF CANCER, 1998, 77 (12) :2088-2097

[7]

Corradi MM, 2002, EUR J INORG CHEM, P2362

[8] Antitumour metallocenes: Structure-activity studies and interactions with biomolecules [J].

Harding, MM ;

Mokdsi, G .

CURRENT MEDICINAL CHEMISTRY, 2000, 7 (12) :1289-1303

[9] Mixed bent sandwich titanium complexes with the [2-(diisopropylamino)ethyl]cyclopentadienyl ligand - Catalysts for the polymerization of ethylene and the dehydrocoupling of phenylsilane [J].

Jutzi, P ;

Redeker, T ;

Neumann, B ;

Stammler, HG .

CHEMISCHE BERICHTE-RECUEIL, 1996, 129 (12) :1509-1515

[10]

KNOX RJ, 1986, CANCER RES, V46, P1972