Synthesis of novel functionalised symmetric bi-2(1H)-pyrazinones

被引：12

作者：

De Borggraeve, WM

Appukkuttan, P

Azzam, R

Dehaen, W

Compernolle, F

Van der Eycken, E

Hoornaert, G

机构：

[1] Katholieke Univ Leuven, Dept Chem, Synth Organ Lab, B-3001 Louvain, Belgium

[2] Helwan Univ, Dept Chem, Cairo 11795, Egypt

来源：

SYNLETT | 2005年 / 05期

关键词：

bis-heterocycle; pyrazinone; Suzuki chemistry; bis(pinacolato)diboron;

D O I：

10.1055/s-2005-863747

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and convenient synthesis for functionalised bi-2(1H)-pyrazinones 9, 11a-h starting from 3,5-dichloro-2(1H)pyrazinones 7, 10a-h is described. The pyrazinone is homo-coupled by means of a Suzuki-type reaction of an in situ generated boronate. The reactions were carried out under conventional heating as well as under microwave irradiation and dramatic improvements in the rates and yields have been observed under the latter conditions.

引用

页码：777 / 780

页数：4

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