Synthesis and evaluation of mimetics of UDP and UDP-α-D-galactose, dTDP and dTDP-α-D-glucose with monosaccharides replacing the key pyrophosphate unit

被引:24
作者
Ballell, L [1 ]
Young, RJ
Field, RA
机构
[1] Univ E Anglia, Sch Chem Sci & Pharm, Ctr Carbohydrate Chem, Norwich NR4 7TJ, Norfolk, England
[2] GlaxoSmithKline, Med Res Ctr, CVU UK Med Chem, Stevenage SG1 2NY, Herts, England
[3] John Innes Ctr Plant Sci Res, Dept Biol Chem, Norwich NR4 7UH, Norfolk, England
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1039/b500418g
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A series of 5'-O-glycosyl-uridine and thymidine derivatives have been prepared as potential mimics of sugar nucelotides and nucleotide-diphosphates. These compounds proved not to be inhibitors of bovine beta-1,4-galactosyltransferase although some showed moderate inhibition of Salmonella dTDP-alpha-D-glucose 4,6-dehydratase (RmlB).
引用
收藏
页码:1109 / 1115
页数:7
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