Design, synthesis and biological evaluation of hetaryl-nucleoside derivatives as inhibitors of chitin synthase

被引：59

作者：

Behr, JB ^{[1
]}

Gourlain, T ^{[1
]}

Helimi, A ^{[1
]}

Guillerm, G ^{[1
]}

机构：

[1] CNRS, UFR Sci, Lab React Select & Applicat, UMR 6519, F-51687 Reims 2, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(03)00239-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report here the design, synthesis and biological evaluation of new models of sugar analogues for chitin synthase. These UDP-GlcNAc mimetics; associate a sugar-mimicking hetaryl group and uridine, linked with different pyrophosphate bioisosteres. The compounds displayed weak inhibition activity on chitin synthase and their antifungal potencies have been assayed against a large variety of pathogenic fungi. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1713 / 1716

页数：4

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