The synthesis of various galactose containing disaccharide nucleosides has been achieved by utilizing the transgalactosylation potential of beta-galactosidase from Aspergillus oryzae. Thus, using p-nitrophenyl-beta-D-galactoside 1 as galactosyl donor, 2-deoxyuridine 2a, uridine 2b, thymidine 2c and adenosine 2d have proven to be useful accepters for the enzyme catalyzed disaccharide nucleoside formation. The regiochemistry of the products 4a - 4d formed after acetylation has been assigned unambiguously by using modem NMR-techniques.
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INST PASTEUR,DEPT BIOCHIM & GENET MOLEC,UNITE CHIM ORGAN,CNRS,28 RUE DR ROUX,F-75724 PARIS 15,FRANCEINST PASTEUR,DEPT BIOCHIM & GENET MOLEC,UNITE CHIM ORGAN,CNRS,28 RUE DR ROUX,F-75724 PARIS 15,FRANCE
ATTAL, S
BAY, S
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INST PASTEUR,DEPT BIOCHIM & GENET MOLEC,UNITE CHIM ORGAN,CNRS,28 RUE DR ROUX,F-75724 PARIS 15,FRANCEINST PASTEUR,DEPT BIOCHIM & GENET MOLEC,UNITE CHIM ORGAN,CNRS,28 RUE DR ROUX,F-75724 PARIS 15,FRANCE
BAY, S
CANTACUZENE, D
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INST PASTEUR,DEPT BIOCHIM & GENET MOLEC,UNITE CHIM ORGAN,CNRS,28 RUE DR ROUX,F-75724 PARIS 15,FRANCEINST PASTEUR,DEPT BIOCHIM & GENET MOLEC,UNITE CHIM ORGAN,CNRS,28 RUE DR ROUX,F-75724 PARIS 15,FRANCE
机构:
INST PASTEUR,DEPT BIOCHIM & GENET MOLEC,UNITE CHIM ORGAN,CNRS,28 RUE DR ROUX,F-75724 PARIS 15,FRANCEINST PASTEUR,DEPT BIOCHIM & GENET MOLEC,UNITE CHIM ORGAN,CNRS,28 RUE DR ROUX,F-75724 PARIS 15,FRANCE
ATTAL, S
BAY, S
论文数: 0引用数: 0
h-index: 0
机构:
INST PASTEUR,DEPT BIOCHIM & GENET MOLEC,UNITE CHIM ORGAN,CNRS,28 RUE DR ROUX,F-75724 PARIS 15,FRANCEINST PASTEUR,DEPT BIOCHIM & GENET MOLEC,UNITE CHIM ORGAN,CNRS,28 RUE DR ROUX,F-75724 PARIS 15,FRANCE
BAY, S
CANTACUZENE, D
论文数: 0引用数: 0
h-index: 0
机构:
INST PASTEUR,DEPT BIOCHIM & GENET MOLEC,UNITE CHIM ORGAN,CNRS,28 RUE DR ROUX,F-75724 PARIS 15,FRANCEINST PASTEUR,DEPT BIOCHIM & GENET MOLEC,UNITE CHIM ORGAN,CNRS,28 RUE DR ROUX,F-75724 PARIS 15,FRANCE