GALACTOSYLATION BY USE OF BETA-GALACTOSIDASE - ENZYMATIC SYNTHESES OF DISACCHARIDE NUCLEOSIDES

被引：23

作者：

BINDER, WH

KAHLIG, H

SCHMID, W

机构：

[1] Institut für Organische Chemie der Universität Wien, A-1090 Vienna

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 07期

关键词：

D O I：

10.1016/0957-4166(95)00216-C

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of various galactose containing disaccharide nucleosides has been achieved by utilizing the transgalactosylation potential of beta-galactosidase from Aspergillus oryzae. Thus, using p-nitrophenyl-beta-D-galactoside 1 as galactosyl donor, 2-deoxyuridine 2a, uridine 2b, thymidine 2c and adenosine 2d have proven to be useful accepters for the enzyme catalyzed disaccharide nucleoside formation. The regiochemistry of the products 4a - 4d formed after acetylation has been assigned unambiguously by using modem NMR-techniques.

引用

页码：1703 / 1710

页数：8

共 34 条

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