Australasian Society for Infectious Diseases guidelines for the diagnosis and treatment of Clostridium difficile infection

被引：63

作者：

Cheng, Allen C. ^{[1
,2
]}

Ferguson, John K. ^{[3
,4
]}

Richards, Michael J. ^{[5
,6
]}

Robson, Jennifer M. ^{[7
]}

Gilbert, Gwendolyn L. ^{[8
]}

McGregor, Alistair ^{[9
]}

Roberts, Sally ^{[10
]}

Korman, Tony M. ^{[11
]}

Riley, Thomas V. ^{[12
,13
]}

机构：

[1] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia

[2] Alfred Hosp, Infect Dis Unit, Infect Prevent & Hlth Epidemiol Unit, Melbourne, Vic, Australia

[3] John Hunter Hosp, Newcastle, NSW, Australia

[4] Univ Newcastle, Newcastle, NSW 2308, Australia

[5] Royal Melbourne Hosp, Victorian Infect Dis Serv, Melbourne, Vic, Australia

[6] Univ Melbourne, Melbourne, Vic, Australia

[7] Sullivan Nicolaides Pathol, Brisbane, Qld, Australia

[8] Ctr Infect Dis & Microbiol, Inst Clin Pathol & Med Res, Sydney, NSW, Australia

[9] Royal Hobart Hosp, Hobart, Tas, Australia

[10] Auckland Dist Hlth Board, Clin Microbiol Lab, LabPlus, Auckland, NZ, New Zealand

[11] Monash Med Ctr, Melbourne, Vic, Australia

[12] Univ Western Australia, Perth, WA 6009, Australia

[13] PathWest Lab Med WA, Div Microbiol & Infect Dis, Perth, WA, Australia

来源：

MEDICAL JOURNAL OF AUSTRALIA | 2011年 / 194卷 / 07期

关键词：

RANDOMIZED CONTROLLED-TRIAL; PSEUDOMEMBRANOUS COLITIS; CLINICAL MICROBIOLOGY; EUROPEAN-SOCIETY; CASE SERIES; METRONIDAZOLE; VANCOMYCIN; EMERGENCE; EPIDEMIC; DIARRHEA;

D O I：

10.5694/j.1326-5377.2011.tb03006.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Clostridium difficile is the most common cause of health care-associated and antibiotic-associated diarrhoea. These guidelines are intended to provide advice to clinicians on the clinical assessment, diagnosis and management of C. difficile infection (CDI). Hypervirulent strains of C. difficile, including PCR ribotype 027 strains recently identified in Australia, have been associated elsewhere with epidemic spread and high rates of severe disease and death. Diagnostic tests include stool culture, polymerase chain reaction-based assays, cell-culture cytotoxicity assays and enzyme immunoassays detecting C. difficile glutamate dehydrogenase, and/or toxin A and/or B. To treat an initial episode and a first recurrence, metronidazole is the preferred antibiotic, with oral vancomycin reserved for severe disease and subsequent recurrences. Surgery should be considered for fulminant disease. MJA 2011; 194: 353-358

引用

页码：353 / 358

页数：6

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