Structures of new dammarane-type triterpene saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal ginseng saponins

被引：161

作者：

Yoshikawa, M ^{[1
]}

Morikawa, T ^{[1
]}

Kashima, Y ^{[1
]}

Ninomiya, K ^{[1
]}

Matsuda, H ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashima Ku, Kyoto 6078412, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 07期

关键词：

D O I：

10.1021/np030015l

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The saponin fraction from the flower buds of Panax notoginseng exhibited protective effect on liver injury induced by D-galactosamine and lipopolysaccharide. From the saponin fraction with hepatoprotective effect, five new dammarane-type triterpene saponins, notoginsenosides-O (1), -P (2), -Q (3), -S (4), and -T (5), were isolated together with nine known protopanaxadiol oligoglycosides. The structures of the new saponins were elucidated on the basis of chemical and physicochemical evidence. The principal dammarane-type triterpene saponins from the roots and flower buds of Panax notoginseng were found to show potent hepatoprotective effects.

引用

页码：922 / 927

页数：6

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