Review of the flavonoids quercetin, hesperetin naringenin. Dietary sources, bioactivities, and epidemiology

被引:679
作者
Erlund, I [1 ]
机构
[1] Natl Publ Hlth Inst, Dept Hlth & Funct Capac, Biomarker Lab, SF-00300 Helsinki, Finland
关键词
flavonoids; quercetin; hesperetin; naringenin; bioavailability; metabolism; biomarker; epidemiology;
D O I
10.1016/j.nutres.2004.07.005
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The bioactivities, dietary sources, bioavailability, metabolism, and epidemiology of 3 flavonoids, quercetin, hesperetin, and naringenin, are reviewed. The use of their plasma concentrations as biomarkers of dietary intake is also discussed. The compounds were chosen because of their significant dietary intakes and promising bioactivities, and in the case of quercetin, because epidemiological studies suggest protection against cardiovascular disease. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:851 / 874
页数:24
相关论文
共 172 条
  • [51] Intake of specific carotenoids and flavonoids and the risk of gastric cancer in Spain
    Garcia-Closas, R
    Gonzalez, CA
    Agudo, A
    Riboli, E
    [J]. CANCER CAUSES & CONTROL, 1999, 10 (01) : 71 - 75
  • [52] Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study
    Geleijnse, JM
    Launer, LJ
    van der Kuip, DAM
    Hofman, A
    Witteman, JCM
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2002, 75 (05) : 880 - 886
  • [53] Ghosal A, 1996, DRUG METAB DISPOS, V24, P940
  • [54] Microbial aromatic acid metabolites formed in the gut account for a major fraction of the polyphenols excreted in urine of rats fed red wine polyphenols
    Gonthier, MP
    Cheynier, V
    Donovan, JL
    Manach, C
    Morand, C
    Mila, I
    Lapierre, C
    Rémésy, C
    Scalbert, A
    [J]. JOURNAL OF NUTRITION, 2003, 133 (02) : 461 - 467
  • [55] Pharmacokinetics and bioavailability of quercetin glycosides in humans
    Graefe, EU
    Wittig, J
    Mueller, S
    Riethling, AK
    Uehleke, B
    Drewelow, B
    Pforte, H
    Jacobasch, G
    Derendorf, H
    Veit, M
    [J]. JOURNAL OF CLINICAL PHARMACOLOGY, 2001, 41 (05) : 492 - 499
  • [56] METABOLISM OF FLAVONOID COMPOUNDS IN GERMFREE RATS
    GRIFFITHS, LA
    BARROW, A
    [J]. BIOCHEMICAL JOURNAL, 1972, 130 (04) : 1161 - 1162
  • [57] Effect of diets based on foods from conventional versus organic production on intake and excretion of flavonoids and markers of antioxidative defense in humans
    Grinder-Pedersen, L
    Rasmussen, SE
    Bügel, S
    Jorgensen, LV
    Dragsted, LO
    Gundersen, V
    Sandström, B
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (19) : 5671 - 5676
  • [58] DISPOSITION OF QUERCETIN IN MAN AFTER SINGLE ORAL AND INTRAVENOUS DOSES
    GUGLER, R
    LESCHIK, M
    DENGLER, HJ
    [J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1975, 9 (2-3) : 229 - 234
  • [59] Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries
    Häkkinen, SH
    Kärenlampi, SO
    Heinonen, IM
    Mykkänen, HM
    Törrönen, AR
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1999, 47 (06) : 2274 - 2279
  • [60] Hall Stephen D., 1999, Drug Metabolism and Disposition, V27, P161