Enantio- and regiocontrol in palladium- and tungsten-catalyzed allylic substitutions

被引：65

作者：

Pretot, R ^{[1
]}

Lloyd-Jones, GC ^{[1
]}

Pfaltz, A ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

PURE AND APPLIED CHEMISTRY | 1998年 / 70卷 / 05期

关键词：

D O I：

10.1351/pac199870051035

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tungsten catalysts with chiral phosphinooxazoline ligands react with 3-aryl-2-propenyl diethyl phosphates and the sodium salt of dimethyl malonate to give the corresponding chiral substitution products with regioselectivities of 3-24:1 and 88-96% ee. A new class of chiral P,N-ligands has been developed which allow efficient regio- and enantiocontrol in analogous Pd-catalyzed allylic substitutions of 1- and 3-aryl-2-propenyl acetates with dimethyl malonate.

引用

页码：1035 / 1040

页数：6

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