Enantioselective Halocyclization Reactions for the Synthesis of Chiral Cyclic Compounds

被引：182

作者：

Chen, Guofei ^{[1
]}

Ma, Shengming ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Lab Mol Recognit & Synth, Hangzhou 310027, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 45期

关键词：

asymmetric synthesis; cyclization; electrophilic addition; halogenation; homogeneous catalysis; ASYMMETRIC IODOCARBOCYCLIZATION REACTION; HYDROXY-CIS-ALKENES; ORGANOSELENIUM REAGENT; TITANIUM COMPLEX; IODOCYCLIZATION; ELECTROPHILES; CYCLIZATIONS; DERIVATIVES; METHOXYSELENENYLATIONS; IODOLACTONIZATIONS;

D O I：

10.1002/anie.201003114

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ground-breaking progress has been made in the synthesis of chiral cyclic compounds from nonchiral unsaturated substrates with a nucleophilic functionality. A number of highly enantioselective electrophilic halocyclizations based on either the interaction of a chiral Lewis acid with an unsaturated substrate or the generation of a chiral electrophilic intermediate in situ from an electrophile and a chiral reagent (see scheme) were developed. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8306 / 8308

页数：3

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