C1-symmetric oxazolinyl sulfoximines as ligands in copper-catalyzed asymmetric Mukaiyama aldol reactions

被引：71

作者：

Sedelmeier, Jorg ^{[1
]}

Hammerer, Tim ^{[1
]}

Bolm, Carsten ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 05期

关键词：

D O I：

10.1021/ol703065x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aryl-bridged C-1-symmetric oxazolinyl sulfoximines are applicable in copper-catalyzed asymmetric Mukaiyama aldol reactions with methyl pyruvate. The resulting alpha-hydroxy esters have been obtained with up to 94% ee in good yields. They contain a quaternary stereogenic center and represent valuable precursors for biologically active molecules.

引用

页码：917 / 920

页数：4

共 47 条

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