Antiviral and immunomodulatory effect of a lyophilized extract of Capparis spinosa L. buds

被引：64

作者：

Arena, A. ^{[2
]}

Bisignano, G. ^{[1
]}

Pavone, B. ^{[2
]}

Tomaino, A. ^{[1
]}

Bonina, F. P. ^{[3
]}

Saija, A. ^{[1
]}

Cristani, M. ^{[1
]}

D'Arrigo, M. ^{[1
]}

Trombetta, D. ^{[1
]}

机构：

[1] Univ Messina, Dept Farmaco Biol, Sch Pharm, I-98168 Messina, Italy

[2] Univ Messina, Dept Surg Sci, Microbiol Unit, I-98168 Messina, Italy

[3] Univ Catania, Dept Pharmaceut Sci, I-95124 Catania, Italy

来源：

PHYTOTHERAPY RESEARCH | 2008年 / 22卷 / 03期

关键词：

Capper spinosa buds; herpes simplex virus type 1 (HSV-1); herpes simplex virus type 2 (HSV-2); antiviral; immunomodulatory; peripheral blood mononuclear cells (PBMCs);

D O I：

10.1002/ptr.2313

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) are common human pathogens that in particular cases can also cause severe problems especially in immunodeficient patients. The present paper reports the antiviral and immunomodulatory properties of a methanolic extract of C spinosa buds (CAP), rich in flavonoids, including several quercetin and kaempferol glycosides. In particular we have investigated whether the in vitro exposure of human peripheral blood mononuclear cells (PBMCs) to CAP might inhibit the replication of HSV-2 and modulate the induction kinetics of IL-12, TNF-alpha IFN-gamma. Our findings have shown that CAP treatment interferes with HSV-2 replication in PBMCs inhibiting the extracellular virus release upregulating their production of IL-12, IFN-gamma and TNF-alpha. One could speculate that CAP may contribute in improving immune surveillance of PBMCs toward virus infection by up-regulating expression of peculiar proinflammatory cytokines; it should thus be successfully employed for treatment of HSV-2 infections in immunocompromised hosts. Copyright (C) 2007 John Wiley & Sons, Ltd.

引用

页码：313 / 317

页数：5

共 31 条

[1] Soluble chemokine binding proteins are also encoded by herpesviruses [J].

Alcami, A ;

Efstathiou, S .

IMMUNOLOGY TODAY, 2000, 21 (10) :526-527

[2]

ALCAMI A, 2003, METH MOL B, V239, P167

[3] Antiviral and immunoregulatory effect of a novel exopolysaccharide from a marine thermotolerant Bacillus licheniformis [J].

Arena, A ;

Maugeri, TL ;

Pavone, B ;

Iannello, D ;

Gugliandolo, C ;

Bisignano, G .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2006, 6 (01) :8-13

[4] Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1 [J].

Armaka, M ;

Papanikolaou, E ;

Sivropoulou, A ;

Arsenakis, M .

ANTIVIRAL RESEARCH, 1999, 43 (02) :79-92

[5]

BAYTOP P, 1984, THERAPY MED PLANTS P

[6]

Bonina F, 2002, J COSMET SCI, V53, P321

[7]

BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77

[8] (6S)-Hydroxy-3-oxo-α-ionol glucosides from Capparis spinosa fruits [J].

Çalis, I ;

Kuruüzüm-Uz, A ;

Lorenzetto, PA ;

Rüedi, P .

PHYTOCHEMISTRY, 2002, 59 (04) :451-457

[9] 1H-indole-3 acetonitrile glycosides from Capparis spinosa fruits [J].

Çalis, I ;

Kuruüzüm, A ;

Rüedi, P .

PHYTOCHEMISTRY, 1999, 50 (07) :1205-1208

[10] Herpes simplex virus and the chemokines that mediate the inflammation [J].

Carr, DJJ ;

Tomanek, L .

CHEMOKINES AND VIRAL INFECTION, 2006, 303 :47-65

← 1 2 3 4 →