Long-term stability of self-assembled monolayers in biological media

被引：202

作者：

Flynn, NT

Tran, TNT

Cima, MJ

Langer, R

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

来源：

LANGMUIR | 2003年 / 19卷 / 26期

关键词：

D O I：

10.1021/la035331e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Undecanethiol (C11H23SH) and tri(ethylene glycol)-terminated undecanethiol (HO(C2H4O)(3)C11H22SH) self-assembled monolayers (SAMs) on clean gold surfaces were prepared and characterized. The SAMs were then immersed into either phosphate-buffered saline or calf serum. The SAM samples were investigated using several analytical techniques at numerous points over the next 35 days. Contact angles and current densities in voltammetry changed dramatically for the PBS samples over the time period, particularly after 21 days. Results indicate substantial loss of the integrity of the SAM. Similar alterations with time were observed for the calf serum samples in both contact angle and voltammetry measurements. X-ray photoelectron spectroscopy indicates that the likely origin is desorption of the alkanethiol moiety as evidenced by appreciable loss of the S 2p signal after 35 days.

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收藏

页码：10909 / 10915

页数：7

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