Phosphoinositide-regulated kinases and phosphoinositide phosphatases

被引：94

作者：

Leslie, NR

Biondi, RM

Alessi, DR ^{[1
]}

机构：

[1] Univ Dundee, MRC, Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland

[2] Univ Dundee, Dept Life Sci, Div Signal Transduct Therapy, Dundee DD1 5EH, Scotland

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 08期

关键词：

D O I：

10.1021/cr000091i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The mechanism by which protein kinase B (PKB) was activated by 3-phosphoinositide-dependent protein kinase (PDK1) in cells was studied. The activity of the downstream effector pathways activated by phosphoinositides were also discussed. The results showed that all PKB isoforms possessed an N-terminal PH domain followed by a kinase catalytic domain and a C-terminal tail.

引用

页码：2365 / 2380

页数：16

共 208 条

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